Ankara Fen Liseliler

Dün AFL de Sayın Vasıf Hasırcı'nın koordinasyonunda Biyoloji Topluluğumuzun düzenlediği seminerde ODTÜ Biyolojiden Y. Doç. Dr. Ayşe Elif Erson'un "Kanser Genetiği" semineri vardı. Semineri 200 öğrenci izledi. Ayşe Elif Erson, insan genom projesinde de çalışmış yüksek lisans ve doktorasını Michigan Üniversitesi genetik bölümünde yapmış genç bir araştırmacı. Yurt içi ve dışında birçok ödülü var. Şu sıralar daha çok meme kanseri genetiği üzerine çalışıyor.

Seminerde öğrenci arkadaşlarımıza hem genetik çalışma üzerine genel bilgi sunuldu hem de araştırmacımızın üzerinde çalıştığı ve son yılların popüler konusu mikro RNA konusunda genel bilgi aktarıldı.

İnsan genom projesinde ortaya çıkan en önemli bulgulardan biri "bir gen, bir protein/enzim" formülünün doğru olmadığı. Bir gen birden fazla enzimi veya proteini yapabiliyor. Sonuçta insanda 25000 civarında gen saptandı.

Hücre bölünmesi çok kontrollü bir işlem. Bölünme hem bu işi indükleyen genlerin (onkogen) hem de baskılayan genlerin (supresor gen) kontrolü altında. Son 4-5 yıl içersinde farkedilen ve de 2007 Nobel Biyoloji ödülünün konusu olan mikro RNA'lar ise hücre bölünmesi ve hücre içi protein sentezinde önemli ölçüde regülasyon yapıyorlar. Bu regülasyonu messenger RNA'ya bağlanarak yapmaktalar. Daha çok hız kısıtlayıcı mikro RNA saptanmış ama az sayıda protein sentezini arttırıcı RNA da var.

Ayşe Elif Hanımla seminer sonrasında neler yapabileceğimizi paylaştık. Bize mikro RNA konusunda uygun bir makale gönderecek; biz onu Biyoloji Topluluğundaki arkadaşlarla 1 ay çalışacağız. Daha sonra AFL KÜtüphanesinde Ayşe Elif Hanımın yönetiminde bir makale saati yapacağız. Bahar aylarında Biyoloji Topluluğuna PCR, Hücre Kültürü teknikleri anlatılacak.

Seminer sonrasında canlı bir soru cevap bölümü yapıldı. Bu arada Ayşe Elif Hanımın AFL Yelken Klübü eğitimlerine katıldığını öğrendik. Kendisiyle birlikte aynı yelken kursuna katılan bizim 3. sınıf öğrencileri de hep birlikte semineri izlediler.

Education:

PhD               2001-2004

Department of Human genetics

University of Michigan, Ann Arbor, MI, USA

Department of Human genetics

University of Michigan, Ann Arbor, MI, USA

 

BSc             1993-1997

Department of Biological Sciences

Middle East Technical University, Ankara, Turkey

 

Publications:

1. Selçuklu DS, Yakicier C, Erson AE. An investigation of microRNA genes mapping to genomic instability regions in breast cancer. Accepted
2. Sukas S, Erson AE, Sert C, Kulah H, A parylene based double-channel micro-electrophoresis system for rapid mutation detection via heteroduplex analysis. Electrophoresis. 2008, 29, 3752–3758
3. Erson AE, Petty EM. microRNAs in Development and Disease. Clinical Genetics. 2008, 74(4):296-306
4. Erson AE, Petty EM. Decreased CHFR expression is associated with early G2/M checkpoint defects in breast cancer cells. Molecular Carcinogenesis. 2004 Jan, 39 (1): 26-33

5. Erson AE, Niell BL, DeMers SK, Rouillard JM, Hanash SM, Petty EM. Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells. Neoplasia. 2001 Nov-Dec,3(6): 521-526.

6. Bespalova IN, Van Camp G, J H Bom S, Brown DJ, Cryns K, DeWan AT, Erson AE, Flothmann K, Kunst HP, Kurnool P, Sivakumaran TA, Cremers CW, Leal SM, Burmeister M, Lesperance MM.  Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss. Hum Mol Genet. 2001 Oct, 10 (22): 2501-2508.

7. Rouillard JM, Erson AE, Kuick R, Asakawa J, Wimmer K, Muleris M, Petty EM, Hanash S. Virtual genome scan:a tool for restriction landmark-based scanning of the human genome. Genome Res. 2001 Aug, 11(8): 1453-1459

Online Publications

1. Tabasi SA, Erson AE . MIRN221 (microRNA 221). Atlas Genet Cytogenet Oncol Haematol. September 2008 .
   URL : http://AtlasGeneticsOncology.org/Genes/MIRN221ID44277chXp11.html
2. Tabasi SA, Erson AE . MIRN222 (microRNA 222). Atlas Genet Cytogenet Oncol Haematol. September 2008 .
   URL : http://AtlasGeneticsOncology.org/Genes/MIRN222ID44278chXp11.html
3. Tuna S, Erson AE . MIRN125A (microRNA 125a). Atlas Genet Cytogenet Oncol Haematol. August 2008 URL:http://AtlasGeneticsOncology.org/ enes/MIRN125AID44325ch19q13.html
4. Akman B, Erson AE. MIRN10B (microRNA 10b). Atlas Genet Cytogenet Oncol Haematol. June 2008 URL : http://AtlasGeneticsOncology.org/Genes/MIRN10BID44292ch2q31.html
5. Selcuklu SD, Yakicier MC, Erson AE . MIRN21 (microRNA 21). Atlas Genet Cytogenet Oncol Haematol. March 2007. URL : http://AtlasGeneticsOncology.org/Genes/MIRN21ID44019ch17q23.html
6. Erson AE, Petty E M . Kidney: Nephroblastoma (Wilms tumor). Atlas Genet Cytogenet Oncol Haematol. September 2006 .
   URL : http://AtlasGeneticsOncology.org/Tumors/WilmsID5034.html

7. Erson AE, Petty EM . TRIM37 (tripartite motif-containing 37). Atlas Genet Cytogenet Oncol Haematol. June 2006
   URL : http://AtlasGeneticsOncology.org/ Genes/TRIM37ID42703ch17q23.html

8. Erson AE, Petty EM . TBX2 (T-box 2). Atlas Genet Cytogenet Oncol Haematol. July 2005 .
   URL : http://www.infobiogen.fr/services/chromcancer/ Genes/TBX2ID42485ch17q23.html

9. Erson AE, Petty EM . PLK1 (polo-like kinase 1 (Drosophila)). Atlas Genet Cytogenet Oncol Haematol. April 2005
   URL : http://www.infobiogen.fr/services/chromcancer/Genes/PLK1ID41747ch16p12.html

10. Erson AE, Petty EM . CHFR (Checkpoint with fork-head associated and ring finger). Atlas Genet Cytogenet Oncol Haematol. June 2004 URL : http://www.infobiogen.fr/services/chromcancer/Genes/CHFRID526.html

Book Chapters

1. Erson AE, Petty EM, Molecular and genetic events in neoplastic transformation, In: Cancer Epidemiology and Prevention, Edited by David Schottenfeld and Joseph F. Fraumeni, October 2006, Oxford University Press

Abstracts and Presentations:

1. Akman B, Erson AE, Potential Roles of Non-coding RNAs in Regulation of an Oncogene Candidate, ESF Non-Coding RNAs: Computational Challenges and Applications, Antalya, Turkey, April 28-30, 2008.
2. Tuna S, Selcuklu SD, Yakicier MC, Erson AE. MicroRNAs localized to common genomic instability regions in breast cancer, ESF Non-Coding RNAs: Computational Challenges and Applications, Antalya, Turkey, April 28-30, 2008.
3. Selcuklu D, Donoghue M, Spillane C, Erson E, Yakicier C. Bioinformatic analysis and microarray expression profiling of miR-21 sensitive transcriptome of MCF7 cells. ESF Non-Coding RNAs: Computational Challenges and Applications, Antalya, Turkey April 28-30, 2008.
4. Selcuklu D, Donoghue M, Yakicier C,  Erson E, Spillane C. Identification of mir-21 targets in breast cancer cells by gene expression profiling. The Consortium for the latest post-genome developments, genome systems meeting, , Manchester, UK, March 17-19, 2008.
5. Duygu SELCUKLU, Prasad KOVVURU, Katherine SCHOUEST, Rachel CLIFTON, Cengiz YAKICIER, Elif ERSON and Charles SPILLANE "Investigation of hsa-miR-21 (MIRN21) targets by bioinformatic analyses and by microarray gene expression profiling in the breast cancer cell line MCF7" Irish Association of Cancer Research Annual Meeting Newcastle, UK, Feb29- Mar 1, 2008.
6. Selcuklu SD, Tuna S,  Yakicier MC, Erson AE, microRNAs in Breast Cancer, EMBO YOUNG SCIENTISTS FORUM, Istanbul, Turkey,  Feb 20-22, 2008
7. Akman B, Erson AE,  Structural Analysis of a 50 kb Region on 17q23, EMBO YOUNG SCIENTISTS FORUM, Istanbul, Turkey,  Feb 20-22, 2008
8. Sapmaz A, Yuce R, Erson AE, Identification of the function and regulation mechanism of USP32, EMBO YOUNG SCIENTISTS FORUM, Istanbul, Turkey, Feb 20-22, 2008.
9. Duygu SELCUKLU, Prasad KOVVURU, Katherine SCHOUEST, Rachel CLIFTON, Cengiz YAKICIER, Elif ERSON and Charles SPILLANE "Investigation of hsa-miR-21 (MIRN21) targets by bioinformatic analyses and by microarray gene expression profiling in the breast cancer cell line MCF7" Irish Association of Cancer Research Annual Meeting Newcastle, UK, 29 Feb-1 Mar 2008.
10. Sukas, A.E. Erson, C. Sert, and H. Kulah, "A Parylene Based Double-Channel Micro-Electrophoresis System for Rapid Mutation Detection," The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007 Conference, Paris, October 2007Selcuklu SD, Yakicier MC, Erson AE, "Identification of microRNAs on common genomic instability regions in breast cancer cells", ESHG, Nice, France, June 16-19, 2007
11. G Martin, P Kovvuru, D Selcuklu, O Shavorskaya, K Schouest, R Clifton, M O' Connell, B O' Sullivan, E Erson, D Higgins, R O' Connor, C Spillane. Functional detection of miRNA candidates acting as oncogenes or tumor suppressors in human cells. Joint Health Research Day, Brookfield Health Sciences Complex, University College Cork, Cork, Ireland, June 15, 2007

12. Akhavan S, Ekim B, Erson AE, Characterization of two ubiquitin specific proteases in cancer, International Symposium on Health Informatics and Bioinformatics, Turkey '07, April 30-2 May, 2007

13. Selcuklu SD, Tuna S, Yakicier MC, Erson AE, A search for microRNAs on genomic instability regions in breast cancer cells, International Symposium on Health Informatics and Bioinformatics, Turkey '07, April 30-2 May, 2007

14. Selcuklu SD, Yakicier C, Erson AE, Investigation of microRNAs in Breast Cancer, Turkish Academy of Sciences-GEBIP Meeting, Oral Communication, Erzurum, 8-10 September, 2006
15. A.E. Erson, Protein Ubiquitination and Degradation: Implications for Breast Tumorigenesis. Gene Regulation and Cancer Symposium, Invited talk, Bilkent University 3-5 May 2006, Ankara, Turkey

16. A.E. Erson, E.M. Petty. Overexpressed Ubiquitin Specific Proteases: Implications in the pathogenesis of breast cancer. American Association for Cancer Research 97th Annual Meeting, Washington DC, USA, April 1-5 2006

17. L.M. Privette, M.E. Gonzalez, A.E. Erson, E.M. Petty.Altered Expression of the Early Mitotic Checkpoint Gene CHFR in Breast Cancers: Implications for Tumor Suppression. American Society of Human Genetics - ASHG, Salt Lake City, Utah. October 25-29, 2005

18. Erson AE, Petty EM, Decreased CHFR expression is associated with checkpoint defects in breast cancer cells, American Association for Cancer Research 94th Annual Meeting, Washington DC, USA, July 11-14 2003

19. Erson AE, Petty EM, Decreased CHFR expression causes checkpoint defects in breast cancer cells, Cancer Research Symposium, University of Michigan, Ann Arbor, MI, USA, October 31 2002

20. Erson AE, Petty EM, Loss of CHFR expression is associated with abnormal mitotic index in breast cancer cells, American Association for Cancer Research 93rd Annual Meeting, San Francisco, CA, USA, April 6-9 2002

21. Erson AE, Niell BL, Petty EM, Multiple 17q genes are amplified and overexpressed in breast cancer, Fall Cancer Research Symposium, University of Michigan, Ann Arbor, MI, USA, October 19 2001

22. Erson AE, Niell BL, Petty EM, Amplification and overexpression of multiple 17q genes in breast cancer, American Society of Human Genetics 51st Annual Meeting, San Diego, CA, USA, October 12-16 2001

23. Bespalova IN, Van Camp G, Bom SJ, Brown DJ, Cryns K, DeWan AT, Erson AE, Flothmann K, Kunst HP, Kurnool P, Sivakumaran TA, Cremers CW, Leal SM, Burmeister M, Lesperance MM. Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss., Oral Communication, American Society of Human Genetics 51st Annual Meeting, San Diego, CA, USA, October 12-16 2001

24. Erson AE, Fisher BL, DeMers S, Hanash S, Petty EM, A discrete amplicon defined by analyses of expressed sequences in breast cancer cells suggests involvement of an unrecognized 17q23 oncogene in breast cancer, Oral Communication, Department of Internal Medicine Research Day, University of Michigan, Ann Arbor, MI, USA, June 2-3 2000

25. Erson AE, Fisher BL, Petty EM, Analysis of TBX2 amplification and overexpression on 17q23 in breast cancer, International Human Genome Meeting, Vancouver, Canada, April 9-12 2000

Awards and Honors:

1. Loreal-TUBA  Young Women Scientists Grant, 2008

2. Young Scientist Award, 2006, Türkiye Bilimler Akademisi (TÜBA)(Turkish Academy of Sciences)

3. Young Investigator Career Project, 2005, Tübitak (The Scientific and Technical Research Council of Turkey)

4. Brigid G. Leventhal Scholar Award, 2003, AACR-Women in Cancer Research, 94^th Annual AACR Meeting, Washington DC, USA

5. Rackham Travel Grant, Rackham/International Institute Travel Grant, University of Michigan, Ann Arbor, MI, USA

6. PhD Scholarship, 1998-2001 Awarded by the Higher Education Council of Turkey